WebDec 1, 2024 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (41,988,261 articles, preprints and more) WebAug 15, 2024 · PINK1(PTEN诱导激酶 1)是Parkin 通路的关键蛋白,由PTEN(磷酸酶 …
PINK1/parkin通路调控线粒体自噬机制的研究进展 - Fudan ...
WebFeb 11, 2024 · Among the PD-associated genes mentioned above, PARK6 encodes PTEN-induced putative kinase1 (PINK1) and PARK2 encodes Parkin, which is a RING/HECT type E3 ubiquitin ligase. Parkin is phosphorylated at serine 65 located within the ubiquitin-like (UBL) domain by PINK1 and then its E3 ligase activity is activated (8, 9).PINK1 is a … Web但是phb2是否参与调控pink1-parkin途径,以及线粒体内外膜受体如何协同调控线粒体自噬还不清楚。 pink1是定位在线粒体内膜的蛋白,在正常的线粒体中,pink1进入线粒体内膜会被线粒体蛋白酶parl识别并剪切,随后pink1被蛋白酶体降解。 cheap challenge coins custom
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WebJun 28, 2024 · 根据自噬体识别途径的不同又可以将线粒体自噬分为两类:(1) 与泛素相关的线粒体自噬,由PINK1 (PTEN Induced Kinase 1)/PRKN (Parkin RBR E3 Ubiquitin Protein Ligase)通路介导;(2) 与泛素无关的线粒体自噬,由线粒体自噬受体蛋白介导 。 WebPINK1 (PTEN induced putative kinase 1) 是一种蛋白激酶。能在整个身体的细胞里表达, … http://cjbmb.bjmu.edu.cn/CN/Y2024/V35/I10/1072 cut pipe lengthwise