Triflic acid, the short name for trifluoromethanesulfonic acid, TFMS, TFSA, HOTf or TfOH, is a sulfonic acid with the chemical formula CF3SO3H. It is one of the strongest known acids. Triflic acid is mainly used in research as a catalyst for esterification. It is a hygroscopic, colorless, slightly viscous liquid and is soluble in … See more Trifluoromethanesulfonic acid is produced industrially by electrochemical fluorination (ECF) of methanesulfonic acid: The resulting CF3SO2F is hydrolyzed, and the resulting triflate salt is reprotonated. Alternatively, … See more Triflic acid is one of the strongest acids. Contact with skin causes severe burns with delayed tissue destruction. On inhalation it causes fatal spasms, inflammation and edema. Like sulfuric acid, triflic acid must be slowly added to See more As an acid In the laboratory, triflic acid is useful in protonations because the conjugate base of triflic acid is nonnucleophilic. It is also used as an acidic … See more WebAug 22, 2012 · Here we describe a Brønsted acid-catalyzed intramolecular Friedel–Crafts alkylation between various aromatic partners and simple alkenes. The reaction is high-yielding, convenient, and atom-economical. We have previously shown that 2-alkenyl-1,1-dichloro-2-silyloxycyclopropanes undergo a domino process involving Ag (I)-promoted …
Advances in Friedel-Crafts Acylation Reactions: Catalytic and …
WebMar 12, 2024 · A series of highly diversified 3-aroylmenadiones was prepared by a new Friedel-Crafts acylation variant/oxidative demethylation strategy. A mild and versatile acylation was performed between 1,4-dimethoxy-2-methylnaphthalene and various activated/deactivated benzoic and heteroaromatic carboxylic acids, in the presence of … WebBeatriz Calvo is an academic researcher from University of Zaragoza. The author has contributed to research in topic(s): Nuclear magnetic resonance spectroscopy & Ligand. The author has an hindex of 6, co-authored 12 publication(s) receiving 76 citation(s). free board game maker
Effective Friedel-Crafts Acylations of O- and C …
WebMay 3, 2013 · Trifluoromethanesulfonic acid in acetonitrile was found to efficiently catalyze Friedel–Crafts alkylations of 1,2,4-trimethoxybenzene with a variety of simple or … WebApr 26, 2004 · In our opinion, consideration of these reactions as `traditional' Friedel–Crafts alkylation involving only the intermediacy of monocationic species 9 cannot explain all the experimental results, such as: (i) the lower reactivity in triflic acid, which is acidic enough to exhaustive O-protonation of the amides; (ii) higher reactivity of 7d ... WebJan 1, 2014 · The reaction mechanism is believed to involve the formation of a mixed anhydride between the carboxylic acid and triflic anhydride which then reacts with thiophene. ... Conversion of the keto acids into acid anhydrides then Friedel–Crafts acylations produced the desired diketone albeit in only 31% yield (over 2 steps) ... free board game instructions