WebAug 2, 2010 · We quantified the degree of similarity in the transcriptional responses among drugs. To this end, we exploited a repository of transcriptional responses to compounds: the Connectivity Map (cMap) (11, 12) containing 6,100 genome-wide expression profiles obtained by treatment of five different human cell lines at different dosages with a set of … http://camda2024.bioinf.jku.at/doku.php/contest_dataset
A novel network pharmacology approach for leukaemia …
WebA systematic method to drug repositioning is to identify candidate drug's gene expression profiles on target disease models and determine how similar these profiles are to approved drugs. Databases such as the CMAP have been developed recently to help with systematic drug repositioning. Methods: To overcome the limitation of connectivity maps ... WebOct 19, 2016 · Connectivity Mapping (CMAP) has been used widely in cancer drug discovery and generally has relied on cancer cell line gene expression and drug phenotype data. Therefore, we took a CMAP approach based on tumor information and clinical endpoints from high grade serous EOC patients. We determined tumor gene expression … alfra martini
Drug discovery using clinical outcome-based Connectivity …
WebSep 29, 2006 · To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. WebAbstract. We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression … WebAbout CLUE. CLUE is a cloud-based software platform for the analysis of perturbational datasets generated using gene expression (L1000) and proteomic (P100 and GCP) … miumiu スマホケース iphone13